Although the company has only been around for five years, Sanuwave (Alpharetta, GA) has big plans for healing bone fractures. Its Pace technology platform uses high-energy acoustic pressure waves to trigger the healing process internally. Sanuwave’s CEO, Chris Cashman, sees a $5 billion U.S. market opportunity for the technology in orthopaedics, $2 billion of which would come from spinal fusion.

With more than six million fractures occurring each year in the United States, Cashman anticipates a $1 billion+ base for using Pace to treat bone fractures. Sanuwave’s orthoPace product received the CE mark in July. The product isn’t FDA approved, but Cashman hopes to begin discussions with the agency this year about how to bring orthoPace to the U.S. market given it’s potential.